Pediatric Follicular Lymphoma

Related Cases: HP-301

  • Typically boys, early-stage disease
  • Locations: Cervical lymph nodes, Waldeyer's ring, or testis
  • Histomorphology: Typically grade 3A morphology; characteristic large, expansile follicles with numerous centroblasts
  • IHC: BCL6+, CD10+, CD43+, BCL2-
  • No t(14;18)(q23;q32)
  • Good prognosis, BCL2+ cases may be associated with higher stage and a worse outcome
  • DDX: florid follicular hyperplasia may have clonal populations of CD10+ B cells by flow cytometry and molecular genetic analysis

Last update: 05/19/2015