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Case 18 - Discussion

Hematopathology Case


Plasma Cell Myeloma with Plasmablastic Features

 The neoplastic plasma cells show significant enlargement of size with large round nuclei and prominent nucleoli in most cells. Occasional cells have anaplastic features. In the extramedullary locations, plasma cell neoplasm (plasmacytoma) with plasmablastic/anaplastic features can closely mimic carcinoma, melanoma or poorly differentiated sarcoma  Therefore, for some poorly differentiated tumors of unknown origin, it is probably worthwhile performing a CD138 staining, particularly when tumor cells show diffuse sheets of growth pattern.