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Case 19 - Discussion

Hematopathology Case

 

Acute Myeloid Leukemia with Monocytic Differentiation

 The peripheral blood of this poor kid shows predominantly monocytes of different stages of differentiation. The monoblasts and promonocytes account for >20% of the white blood cells, so this case meets the diagnosis of acute myeloid leukemia. The monoblasts account for <80% of cells and this is no obvious myeloid component. I do not have the cytogenetic data, but this case might belong to AML with t(9;11) or acute monocytic leukemia (FAB, M5b) if no cytogenetic findings.