Asteroid bodies: Asteroid
striking cytoplasmic inclusions in giant cells of granulomas of
many types including those of sarcoidosis, tuberculosis,
leprosy, fungal infections, schistosomiasis, and lipoid and
foreign body types. They vary in size from 5 to 30 Ám and have
up to 30 rays forming a star-like, spider, or umbrella pattern.
The surrounding cytoplasm is vacuolated . There is
controversy about their composition. Some believe the radiating
spokes are composed of cytoplasmic filaments , and others
believe they are composed of microtubular components [3,4]. In
any case, the pathophysiologic changes that produce the Asteroid
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vantage point. Pathol Annu 1979 Part 1; 14:405-439.
Kirkpatrick C, Curry A, Bisset
D. Light- and electron-microscopic studies on multinucleated
giant cells in sarcoid granuloma: new aspects of asteroid
and Schaumann bodies. Ultrastructural Pathol 1988;
Cain H, Kraus B. Asteroid
bodies: derivatives of the cytosphere. An electron
microscopic contribution to the pathology of the cytocentre.
Virchows Arch B Cell Path 1977; 26:119-132.
Gadde P, Moscovic E. Asteroid
bodies: products of unusual microtubule dynamics in monocyte-derived
giant cells. An immunohistochemical study. Histol &
Histopathol 1994; 9:633-642.