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Case 48 - Discussion

Hematopathology Case



CD3 CD20
CD15 CD30

Diagnosis: Diffuse Large B-Cell Lymphoma, with expression of CD30

The lymph node shows diffuse infiltration by large tumor cells with irregular nuclear contour, prominent nucleoli and moderate to abundant cytoplasm. There are scattered large multinucleated atypical cells. Frequent mitotic figures and numerous apoptotic bodies are present. The tumor cells are positive for CD20 and CD30, but are negative for ALK-1, CD15, CD3, CD4, CD5, CD7, CD8 and AE1/ AE3.