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Case 66 - Discussion

Hematopathology Case

 

Light Chain Myeloma (LCM)

(Bence Jones Myeloma)

  • 15-20% of all myeloma cases
  • More malignant course compared to classic myeloma
  • Extremely rapid doubling time
  • Tendency for more osteolytic lesions
  • Increased hypercalcemia
  • Higher incidence of renal failure
  • Higher incidence of amyloidosis and plasma cell leukemia
  • Renal failure, principle cause of death
  • Lambda LCM has 3 worse prognosis than kappa LCM