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Case 79 - Discussion

Hematopathology Case

 

 

CD20

CD20

CD3

CD3

CD4

CD4

CD8

CD8

CD31

CD31

CD34

CD34

MPO

Lysozyme

Ki67 Ki67
   

Diagnosis: myeloid sarcoma of lymph node

Microscopic description:

The architecture of the lymph node is almost entirely effaced by a diffuse paracortical, perisinusoidal and sinusoidal proliferation of medium-size mononuclear cells. The atypical cells have irregular nuclei with often finely dispersed chromatin and one to multiples small nucleoli. There are admixed eosinophilic precursors as well as apparent mature eosinophils, small lymphocytes, histiocytes, and plasma cells.  A few secondary lymphoid follicles are noted. The atypical mononuclear cells express CD31, CD34, TdT, myeloperoxidase, lysozyme (at least partially), CD7, and CD56 (partially). These findings are consistent with a diagnosis of myeloid sarcoma.

 

Peripheral blood smear and bone marrow biopsy were evaluated and described in hematopathology case 81.