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Case 93 - Discussion

Hematopathology Case


Infectious Mononucleosis

  • A disease due to infection by Epstein-Barr virus (EBV)
  • The atypical lymphocytes are mainly CD8+ T lymphocytes which are responding to virus-infected B cells.
  • Morphology of atypical cells: they are large in size and have pleomorphic  nuclei, moderately condensed chromatin, and prominent nucleoli.  The cytoplasm is abundant and basophilic, and the staining is denser on the edge cytoplasm. The cytoplasmic border often shows scapuling
  • The most commonly used diagnostic criterion is the presence of 50% lymphocytes with at least 10% atypical lymphocytes
  • Note that a similar blood film can occur in other viral conditions, particularly cytomegalovirus