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Case 114 - Discussion

Hematopathology Case



CD20, 10 CD20, 20
Diffuse Large B-cell Lymphoma of Testicle

Diffuse Large B-Cell Lymphoma of Testis

  • Often seen in old male

  • The most common bilateral testicular neoplasms in old patients are lymphoma

  • The most common type of lymphoma is diffuse large B-cell lymphoma

  • Morphologically, the tumor cells diffusely involve testicular parenchyma with intertubular and intratubular infiltration. The tumor cells are large in size and have irregular nuclei and moderate amount of cytoplasm.

  • The major differential is seminoma, which typically has incomplete fibrous septa with mixed reactive small lymphocytes; the tumor cells are larger with round nuclei and one prominent central inclusion-like nucleolus; the cytoplasm is abundant and clear. Seminoma cells are positive for PLAP, CD117, and OCT3/4 with no expression of cytokeratin, CD45, and CD20.