The major differential diagnosis of
this case includes "acute myeloid leukemia with monocytic
differentiation", "blastic plasmacytoid dendritic cell neoplasm" and
"NK/T cell lymphoma, nasal type". I do not have the information of
Acute myeloid leukemia with
monocytic differentiation: flow cytometry data would be very
helpful, particularly expression status of CD14, CD34, CD64, CD123
Blastic plasmacytoid dendritic cell
neoplasm: again flow cytometry data would be very helpful. In
addition, immunostains for CD123, TCL1 and TdT can be useful. Tumor
cells typically express CD68 with cytoplasmic dotted pattern;
NK/T cell lymphoma, nasal type:
not likely since NK/T-cell lymphoma should be positive for CD3 by
immunostaining. Again, flow cytometry for cCD3 would be helpful.
Also, EBER-ISH is usually positive.