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Case 134 - Discussion

Hematopathology Case





Littoral Cell Angioma of Spleen

  • Mixture of papillary and cystic areas

  • Lined by neoplastic cells deriving from normal splenic lining--littoral cells

  • Tumor cells positive for endothelial and histiocytic antigens, but negative for CD8

  • Normal endothelium of venous sinuses expresses endothelial antigens and CD8

  • Typical markers for littoral  cell angioma: CD31+, CD68+, CD163+, CD21+, FVIII+; CD34-, CD8-