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Case 146 - Discussion

Hematopathology Case

 

CD3

CD56

Granzyme B

Ki67

 

EBER

 

 

 

Nasal NK/T Cell Lymphoma

  • More common in Asian
  • HE: massive necrosis, prominent vascular proliferation, angiocentric, epitheliotropism
  • CD2+, sCD3-, cCD3+, CD56+, cytotoxic markers + (TIA-1, perforin, and granzyme B)
  • EBV+ in most cases
  • No clonal TRG@ gene rearrangement
  • Associated with hemophagocytic syndrome