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Case 150 - Discussion

Hematopathology Case


Metastatic Lobular Carcinoma of Breast

Lobular carcinoma of breast may initially present as metastasis without breast symptoms. I have seen a case initially presented with ascites (Case-0390). In this lymph node, the tumor cells diffusely infiltrate the interfollicular area with relatively preserved architecture of lymph node. The tumor cells are admixed with lymphocytes, and compared with surrounding lymphocytes, they are larger and have round nuclei with fine chromatin and small nucleoli, which may mimic large cell lymphoma. However, frequent intracytoplasmic lumen is noted. In the extranodal soft tissue, the tumor cells are arranged in classic Indian file pattern.