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Case 151 - Discussion

Hematopathology Case

 

Review of peripheral blood smear showed erythroblastosis, many tear-drop red blood cells and giant platelets, suggestive of myelofibrosis.

 

Extramedullary Hematopoiesis (EMH)

EMH often occurs in patients with marked marrow fibrosis. The involved lymph node typically has preserved architecture with marked expanded sinuses, which contain all marrow elements, including myeloid cells, erythroid cells, and scattered megakaryocytes. The megakaryocytes can mimic metastatic tumor cells or Hodgkin lymphoma cells.