Back to Homepage

Case 170 - Discussion

Hematopathology Case

 

Cytokeratin

CD45

CD3

CD20

CD79a

CD138

Kappa light chain (ISH)

Lambda light chain (ISH)

EBER

HHV8

 

Large B-Cell Lymphoma

  • Some cases of poorly differentiated large B-cell lymphoma, particularly in HIV+ patients, may not express conventional B-cell markers (CD20, CD79a and PAX5). CD138 is positive in most of cases, but can be negative; and cytoplasmic light chains can be negative in substantial proportion of cases;

  • BOB1 and OCT2 are usually positive in most of the cases;

  • A small proportion of cases may even have aberrant expression of CD3, weakly or strongly. However, PCR for T-cell receptor gene rearrangement  is negative.