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Case 172 - Discussion

Hematopathology Case


Classic Hodgkin Lymphoma, Lymphocyte Depletion Type

  • Least frequently subtype, ~1% of CHL
  • Usually EBV+
  • Diffuse fibrosis type:
    • Hypocellular infiltrate, sparse heterogeneous background cells
    • Disordered and diffuse reticulin fibrosis, no organized collagen bands
  • Reticular variant:
    • Sheets of atypical cells, many bizarre and anaplastic RS cells
    • Tumor cells with characteristic CHL immunophenotype