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Case 179 - Discussion

Hematopathology Case

 

CD20

CD138

CD10

MUM1

CD30

CD30

 

 

Other markers: CD45+, CD79a+, BCL2+, CD3-, CD43-, ALK1-

 

 

Sinusoidal CD30+ Large B-Cell Lymphoma

  • Age: 36-82 years; mean, 63.2 years
  • Male to female ratio,1:1.2
  • Histopathology:
    • Typically sinusoidal infiltrative pattern; may have foci of confluent growth
    • Most cases composed predominantly of large pleomorphic cells with occasional Reed-Sternberg-like cells
    • Some cases consist predominantly of large monomorphic lymphoid cells
    • Necrosis and admixed granulocytes commonly present
  • IHC:
    • Positive for CD30 and CD20 or CD79a
    • Negative: ALK-1
    • EBV present in a small subset of cases
  • Aggressive clinical behaviors
  • Ref: Mod Pathol. 2000 Mar;13(3):223-8.