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Case 203 - Discussion

Hematopathology Case








Classic Hodgkin Lymphoma Involving Bone Marrow
  • Hodgkin lymphoma involves bone marrow in 5-15% of cases;

  • Characteristically by discrete, spacing-occupying lesions that often clearly demarcated from normal marrow;

  • Mixed infiltration by small lymphocytes, histiocytes, plasma cells and eosinophils

  • Fibrosis mostly present

  • Lymphoma cells may mimic megakaryocytes; typically, megakaryocytes have more pale-pink cytoplasm, whereas lymphoma cells has more clear cytoplasm with often contraction artifact. Very importantly, megakaryocytes do not have the large eosinophilic nucleoli as seen in Hodgkin lymphoma cells.