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Case 207 - Discussion

Hematopathology Case


Plasma Cell Leukemia

  • Criteria: neoplastic plasma cells > 20% of total leukocytes, or absolute count > 2 109/L

  • Patients are younger, compared with patients with classic plasma cell myeloma

  • Significantly more common lymphadenopathy, organomegaly, and renal failure

  • Less common lytic bone lesion and bone pain

  • Most cases lack CD56 expression

  • More aggressive clinical behaviors