- Circulating mantle cells lymphoma (MCL) cells may be present
in the peripheral blood, and occasionally can reach a
substantially high number;
- The morphology of circulating MCL cells depends on the
morphologic subtype of tumor cells. For the most common small cell
variant of MCL, the circulating tumors closely resemble CLL cells.
However, compared to the CLL cells, MCL cells are slightly larger
with more variable cell sizes and more
nuclear irregularities. Some MCL cells are small with round nuclei
and condensed chromatin, whereas others are medium sized with
slightly dispersed chromatin, more cytoplasm, or a distinct small nucleolus.
- For the blastoid or pleomorphic variant, the tumor cells are
medium or large in size. The chromatin is usually open, resembling
blasts. However, the nucleolus is usually small or inconspicuous,
even in cells with pleomorphic morphology.