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Case 210 - Discussion

Hematopathology Case

 

The patient had a history of mycosis fungoides.

 

Sezary Cells

  • Classic features of Sezary syndrome: circulating Sezary cells, erythroderma, hyperkerotosis of the palms and soles, lymphadenopathy

  • Criteria for Sezary syndrome: peripheral lymphocytosis, clonal T-cells in the peripheral blood, elevated CD4/CD8 ration >10, abnormal immunophenotype

  • Sezary cells: medium in size, larger than mature lymphocytes, ceribriform nuclei and scant cytoplasm

  • Typical immunophenotype: CD3+, CD4+, CD8-, CD7-