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Case 230 - Discussion

Hematopathology Case


Classic Hodgkin Lymphoma, Mixed Cellularity Type, Histiocyte-Rich Variant

  • This case closely resembles sarcoidosis at low magnification due to prominent aggregates of histiocytes; however, the granulomas in sarcoidosis are usually more well-defined and compact. Another differential diagnosis is Lennert lymphoma. With the differential diagnosis in mind, careful searching for Hodgkin cells/RS cells or atypical lymphocytes at high-power is the key.

  • An important personal lesion: we often need to think outside the box, not just focusing on the "major" or "obvious" lesions on the slides. Also need to pay attention to the background, where the real pathology changes hide occasionally.