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Case 231 - Discussion

Hematopathology Case

 

Plasmacytoma

  • This breast lesion shows sheets of dyscohesive anaplastic cells with broad pale-eosinophilic cytoplasm. The tumor cells are negative for cytokeratin, T-cell/B-cell markers and S100.

  • Neoplastic plasma cells may show a variety of morphologic features, which may not look like plasma cells at all. In some cases, scattered tumors cells with typical plasma cell morphology may be present with careful observation at high-power. Touch-imprint and smear may be very helpful since tumor cells may show better plasma cell features in cytology specimens.

  • For poorly differentiated tumors, it is probably worthwhile to keep several differential diagnoses in mind: poorly differentiated carcinoma, melanoma, rhabdomyosarcoma, anaplastic large cell lymphoma - null cell type, plasmablastic/anaplastic plasma cell neoplasm, and plasmablastic/anaplastic/immunoblastic B-cell lymphoma.