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Case 235 - Discussion

Hematopathology Case


Acute Myeloid Leukemia with t(8;21)(q22;q22) (RUNX1-RUNX1T1)

  • Translocation of RUNX1 (core binding factor-α or AML1) on 21q22 and RUNX1T1 (ETO) on 8q22

  • Morphology:

    • Blasts:

      • Cytoplasmic hofs, occasional Auer rods

      • Characteristic large, salmon-colored granules

      • May resemble left shifted granulocytes with abundant granules and cytoplasm

    • Dysplastic maturing neutrophils with nuclear abnormalities

    • Background eosinophilia without morphologic abnormalities

  • Immunoprofile:

    • CD34, MPO, variably CD13 and CD33

    • Weak CD19 in most cases

    • CD56, PAX5 and CD79a in some cases

  • Favorable prognosis in the absence of KIT mutations

Reference: Hematopathology, 2010