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Case 247 - Discussion

Hematopathology Case

 

Cytokeratin S100
CD4 CD45

CD43

CD163

CD68

Lysozyme

   

 

Histiocytic Sarcoma

  • Malignant cells resembling histiocytes: large eccentric placed, oval nuclei with vesicular chromatin and a prominent single, irregular nucleolus; nuclei may be grooved; cytoplasm is abundant and eosinophilic, and may be foamy or vacuolated.
  • Positive markers: CD68, CD163, CD14, CD4, CD11c, lysozyme, alpha 1-antitrypsin, CD45, HLA-DR
  • S100 may be positive
  • Negative markers: follicular dendritic markers (CD21, CD23, CD35) and langerhans cell markers (langerin, CD1a)
Reference: Hematopathology: Expert Consult. 2010