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Case 249 - Discussion

Hematopathology Case

 

Diagnosis: Interdigitating Dendritic Cell Sarcoma

Follicular dendritic cell sarcoma v.s. Interdigitating dendritic cell sarcoma

 

Follicular dendritic cell sarcoma

Interdigitating dendritic cell sarcoma

Location of

Normal Counterpart

Germinal Center

T cell areas (paracortex and interfollicular areas of

lymph node, splenic periarteriolar lymphoid sheaths)

Origin

Mesenchymal

the monocyte-macrophage lineage

Electron microscopy

Numerous long, slender cytoplasmic processes

connected by desmosomes

Complex interdigitating cellular junctions

CD21

+

CD35

+

S100

+

CD23

+

Clusterin

+

CD1a

HMB-45

CD3

CD20

CD45

+/−

CD68

Lysozyme

  • CD21: CR2-complement component (3d) receptor 2, and EBV receptor;

  • CD23: IgE Fc receptor, FcεRII;

  • CD35: erythrocyte complement receptor 1 (CR1, also known as  C3b/C4b receptor and immune adherence receptor)

  • Clusterin: designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2). A marker of ALCL.