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Case 251 - Discussion

Hematopathology Case


Classic Hodgkin Lymphoma, Lymphocyte Depletion Subtype

  • Least frequently subtype, ~1% of CHL

  • Usually EBV+

  • Diffuse fibrosis type:

    • Hypocellular infiltrate, sparse heterogeneous background cells

    • Disordered and diffuse reticulin fibrosis, no organized collagen bands

  • Reticular variant:

    • Sheets of atypical cells, many bizarre and anaplastic RS cells

    • Tumor cells with characteristic CHL immunophenotype