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Case 258 - Discussion

Hematopathology Case

 

Megaloblastoid Changes of Erythroid Precursors

  • The patient developed myelodysplastic syndrome with increased ring sideroblasts. Multilineage dysplasia is present but only erythroid dysplasia is shown here. The erythroid precursors show megaloblastiod changes with coarse chromatin and irregular nuclear contours, which are different to the megaloblastic changes seen in the previous case.