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Case 270 - Discussion

Hematopathology Case

 

AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.1); (RPN1-EVI1)

 Primarily in adults

 Peripheral blood with thrombocytosis, giant agranular platelets

 Bone marrow: myelodysplastic findings, particularly monolobated or hypolobated megakaryocytes

 Blasts: myeloid, monocytic or megakaryoblastic

 Often aberrant expression of CD7; often associated with 7-

 Poor prognosis