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Case 276 - Discussion

Hematopathology Case

 

Sickle Cell Disease (HbSS)

  •  β chain mutation, 6 Glu →Val

  • Clinical: Moderate to severe anemia

  • CBC: HGB 6-10, normal MCV

  • HbS > 80%, HbF 1-20%, HbA2 1-4%, HbA 0%

  • Blood smear: sickle cells, polychromasia, target cells, Howell-jolly bodies, Pappenheimer bodies