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Case 278 - Discussion

Hematopathology Case

 

Hb C Disease (HbCC)

  • β chain mutation, 6 Glu →Lys

  • Clinical: Mild to moderate hemolytic anemia, splenomegaly

  • CBC: Mild microcytosis, MCV 70-72

  • HbC 90%, HbF 7%, HbA2 3%, HbA 0%

  • Blood smear: Numerous small target cells, microspherocytes; HbC crystal: rod or polygonal, intra-/extra-cellular.