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Case 289

Hematopathology Case

Clinical information:

 

A 21-year-old Asian male with a history of CVID presented with fatigue and shortness of breath on light exertion. His peripheral blood revealed severe pancytopenia, including marked normocytic anemia (hemoglobin 7.0g/dL, MCV 85.7fL) and profound thrombocytopenia (platelets count, 34109/L). The coagulation profile displayed elevated activated partial thromboplastin time and prothrombin time but normal fibrinogen level (353 mg/dL). A bone marrow biopsy was performed.

 

 

 

 

 

Peripheral blood smear, 100

Peripheral blood smear, 100

 

 

Bone marrow aspirate smear, 100

Bone marrow aspirate smear, 100

 

 

Bone marrow aspirate smear, 100

Bone marrow aspirate smear, 100

 

 

Bone marrow core biopsy. HE, 4

Bone marrow core biopsy. HE, 20

 

 

Bone marrow core biopsy. HE, 40

Bone marrow core biopsy. HE, 40

 

 

 

 

Click here for diagnosis and discussion

 

Case from: Department of Pathology, University of Colorado Denver, Aurora, Co