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Case 290 - Discussion

Hematopathology Case


Acute Myeloid Leukemia with Charcot Leyden Crystals

  • Charcot Leyden crystals (CLCs) are composed of lysophospholipase, which is normally found in eosinophils and may be seen in inflammatory conditions or hematologic malignancies with eosinophilia;

  • CLCs in acute myeloid leukemia are rare and often accompanied by extensive bone marrow necrosis, as seen in our case;

  • Morphologic evidence of increased eosinophils may or may not be present. The source of lysophospholipase and CLCs in cases lacking eosinophilia is unknown.

  • Reference
    • American Journal of Hematology 73:141 (2003)
    • Blood 120; 3 (2012)
    • American Journal of Hematology 82 (11); 1029 (2007)
    • Leuk Res 4(12):e336-8 (2010)