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Case 302 - Discussion

Hematopathology Case





The is a typical Whipple disease associated lymphadenopathy with classic clinical presentations and histological features. The lymph node shows markedly expanded sinuses with distortion of nodal architecture. The sinuses contain abundant histiocytes with small vacuoles in the cytoplasm. In addition, there are frequent large empty spaces in the sinuses, a feature also noted in the intestinal biopsy. PAS highlights numerous rod-shaped bacteria in the cytoplasm. PCR study detected the presence of T. Whippelii


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