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Case 304 - Discussion

Hematopathology Case

 

CD138

  • Cytogenetic/FISH studies: Positive for t(11;14), CCND1/IGH@ rearrangement.

  • Diagnosis: Plasma cell myeloid with t(11;14)

Plasma cell myeloma with t(11;14)

  • The neoplastic plasma cells mimic plasmacytoid lymphocytes on smears and closely resemble lymphocytes on H.E sections;

  • Tumor cells positive for CD138 but negative for CD45

  • Often express CD20 and cyclin D1

  • Often t(11;14)(q13;q32)