Diagnosis: EBV-associated transformation of mantle cell lymphoma
into a high-grade B-cell lymphoma
Mantle cell lymphoma
(MCL) patient surviving nearly 20 years despite persistent
transformation to a high-grade B-cell.
infection in the large lymphoma cells.
Loss of CD5, cyclin
D1 and SOX11 expression in the transformed cells.
Reference: Case of Epstein-Barr virus-associated transformation
of mantle cell lymphoma. Terasawa T, Ohashi H, Utsumi M, Tsushita K,
Kinoshita T, Nakamura S, Saito H. Am J Hematol. 2003