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Case  - Discussion

Hematopathology Case







FISH on the 2015 resection sample positive for CCND1/IGH@ rearrangement


  • Diagnosis: EBV-associated transformation of mantle cell lymphoma into a high-grade B-cell lymphoma

  • Interesting features:

    • Mantle cell lymphoma (MCL) patient surviving nearly 20 years despite persistent disease.

    • MCL with transformation to a high-grade B-cell.

    • Positive EBV infection in the large lymphoma cells.

    • Loss of CD5, cyclin D1 and SOX11 expression in the transformed cells.

  • Reference: Case of Epstein-Barr virus-associated transformation of mantle cell lymphoma. Terasawa T, Ohashi H, Utsumi M, Tsushita K, Kinoshita T, Nakamura S, Saito H. Am J Hematol. 2003 Jul;73(3):194-9.