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Case 305

Hematopathology Case

Clinical information:

 

  • A 74-year-old female presented to the emergency department with sharp, stabbing abdominal pain.
  • Her past medical history was significant for a long standing history of mantle cell lymphoma, initially diagnosed in 1996, with multiple recurrences in the small intestine and colon.
  • In 2005 and 2008, the patient underwent right hemicolectomy and segmental resection of the small intestine, respectively, both of which were extensively involved by mantle cell lymphoma.
  • During this hospitalization in 2015, the patient was found to have leakage from the previous anastomosing site. She subsequently had further resection of the small intestine.

Previous samples with mantle cell lymphoma in 2005 and 2008

 

 

 

HE, 2

HE, 4

 

 

HE, 10

HE, 20

 

 

HE, 20

CD3

 

 

CD5

CD20

 

 

CD23

Cyclin D1

 

 

SOX11

MIB1

 

 

EBER - ISH

FISH positive for CCND1/IGH@ rearrangement

 

 

 

Current resection sample in 2015

 

 

 

HE, 2

HE, 4

 

 

HE, 10

HE, 20

 

 

HE, 20

HE, 40

 

 

HE, 40

HE, 40

 

 

HE, 40

HE, 40

 

 

 

 

Click here for diagnosis and discussion

 

Case from: Department of Pathology, University of Colorado Denver, Aurora, Co