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Case 308 - Discussion

Hematopathology Case

 

Diffuse medium to large cell component

 

BOB1

CD15

CD20

CD3

CD30

CD45

 

EBER-ISH

 

 

 

Hodgkin Lymphoma-like component

 

BOB1

CD15

CD20

CD3

CD30

CD45

 
EBER-ISH  

 

 

B-cell lymphoma with diffused large cell lymphoma and classic Hodgkin lymphoma components

  • This interesting case shows two distinct morphologic components, one with diffuse large B-cell lymphoma features and the other one with classic Hodgkin lymphoma findings. EBV is detected in both areas;

  • They are very likely clonal related although PCR studies on microdessected tumors failed to detect clonal IGH gene rearrangements.