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Case 309 - Discussion

Hematopathology Case

MEL-A S100


  • The patient had no history of melanoma. Morphologically, the tumor cells show diffuse infiltration, and they have large round nuclei with vesicular chromatin, prominent eosinophilic nucleoli, and ample pale-pink cytoplasm. Occasional cells have a large intranuclear inclusion, and rare cells contain intracytoplasmic brown pigment. The histologic findings are very suspicious for a melanoma, which was confirmed by immunostains;

  • Melanoma cells may mimic lymphoma. In this case, the tumor cells resemble immunoblasts although other features navigate away from lymphoma.