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 ENJOY PATHOLOGY

Steamboat Lake, Clark, CO. 11/25/12

Hematopathology Case Diagnosis

Case #

Clinical Information

Final Diagnosis
311 55 F. Fever, night sweats and systemic lymphadenopathy Angioimmunoblastic T-cell lymphoma (AITL)
310 44 M. 2.7 cm right cervical mass Lymphadenoma of parotid gland
309 59 M. 2.7 cm abdominal wall mass Melanoma with immunoblastic morphology
308 54 M. Large left inguinal lymph node B-cell lymphoma with DLBCL and classic Hodgkin lymphoma components
307 39 M. HIV+, several enlarged left inguinal lymph nodes Kaposi sarcoma of lymph node
306 60 M. Pancytopenia and splenomegaly Peripheral T-cell lymphoma, NOS, with gamma/delta T-cell derivation
305 74 F. Colon and small intestinal masses EBV-associated high-grade transformation of mantle cell lymphoma
304 69 F. Bone lesion in the right femur Plasma cell myeloma with t(11;14)
303

67 M. 3.1 cm skin lesion and right axillary lymphadenopathy

Blastic plasmacytoid dendritic cell neoplasm (BPDCN)
302 51 M. Fever, diarrhea and lymphadenopathy. Axillary lymph node Whipple disease
301 9 M. Enlarge right tonsil Pediatric follicular lymphoma
300 29 F. Right cervical lymphadenopathy Kikuchi-Fujimoto lymphadenitis
299 74 M. Persistent leukocytosis and bone marrow biopsy Atypical chronic myeloid leukemia (aCML) with CSF3R mutation
298 31 M. Cytopenia and splenomegaly. Bone marrow biopsy Bone marrow with infiltration by hepatosplenic T-cell lymphoma
297 61 F. Bone marrow biopsy Metastatic angioimmunoblastic T-cell lymphoma
296 68 F. Macrocytosis and neutropenia. Bone marrow biopsy Myelodysplastic syndrome with 5q deletion
295 86 F. Bone marrow biopsy Acute myeloid leukemia, blasts mimicking promyelocytes
294 39 M. Left cervical lymphadenopathy Metastatic nasopharyngeal carcinoma with sinusoidal infiltrative pattern
293 35 M. Pancytopenia and bone marrow biopsy Acute myeloid leukemia with t(15;17)
292 53 M. Bone marrow biopsy Metastatic classic Hodgkin lymphoma
291 66 F. Macrocytosis and neutropenia. Bone marrow biopsy Myelodysplastic syndrome with 5q deletion
290 63 F. Pancytopenia and bone marrow biopsy Acute Myeloid Leukemia with extensive necrosis and Charcot-Leyden crystals
289 21 M. Anemia and bone marrow biopsy Megaloblastic Anemia, Mimicking Microangiopathic Hemolytic Anemia
288 68 F. Bone marrow biopsy Markedly left shift granulopoiesis, mimicking AML
287 71 M. Inguinal lymph node Metastatic melanoma, mimicking histiocytic lesion or lymphoma
286 24 F. Cervical lymphadenopathy Kikuchi-Fujimoto lymphadenitis
285 31 F. Cervical lymphadenopathy Kikuchi-Fujimoto lymphadenitis
284 24 F. Cervical lymphadenopathy Kikuchi-Fujimoto lymphadenitis
283 72 F. Cytopenia and bone marrow biopsy Megaloblastic Anemia
282 53 F. An incidental splenic mass Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor
281 64 F. Bone marrow biopsy Acute myeloid leukemia with inv(3)(q21q26.2)
280. 68 F. Anemia with MCV 112. Peripheral blood smear Megaloblastic Anemia
279. 37 M. History of thalassemia. Peripheral blood smear Basophilic stippling
278. 23 M. Peripheral blood smear. Hb C Disease (HbCC)
277. 27 M. Peripheral blood smear Hb SC
276. 16 M. Peripheral blood smear Sickle Cell Disease (HbSS)
275. 75 M. Peripheral blood smear Iron Deficiency Anemia
274. 48 F. Serum monoclonal IgM = 5.6g. Bone marrow biopsy Lymphoplasmacytic Lymphoma / Waldenström's Macroglobulinemia
273. 76 M. Fever for 6 days. Peripheral blood smear Histoplasmosis
272. 64 F. Bone marrow biopsy AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.1)
271. 65 F. Bone marrow biopsy Markedly Left-Shifted Granulopoiesis
270. 66 F. Bone marrow biopsy AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.1)
269. 65 M. Inguinal lymph node Small Lymphocytic Lymphoma with Herpes Simplex Virus Infection
268. 13 M. Peripheral blood smear Sickle Cell Disease
267. 62 M. Recently onset of pneumonia. Peripheral blood smear Cold Agglutination
266. 18 M. Peripheral blood smear May-Hegglin Anomaly
265. 11 M. Peripheral blood smear Hereditary Spherocytosis
264. 21 M. Peripheral blood smear Chediak-Higashi Syndrome
263. 61 M. Pancytopenia. Bone marrow biopsy Auer rods in AML
262. 73 M. Pancytopenia, monoclonal gammopathy. Bone marrow biopsy Plasma cell myeloma with lymphoid appearance
261. 68 F. Pancytopenia. Bone marrow biopsy Trilineage dysplasia in MDS
260. 45 M. Multiple skin lesions T-Cell Prolymphocytic Leukemia with Skin Involvement
259. 55 M. Bone marrow biopsy for routine follow-up of transplant Mycobacterial Granuloma in Bone Marrow
258. 58 M. Pancytopenia. Bone marrow biopsy Erythroid Megaloblastoid Changes in MDS
257. 76 F. Anemia. Bone marrow biopsy

Megaloblastic Anemia

256. 67 M. Axillary lymph node Blastoid Mantle Cell Lymphoma Transformed from Classic Mantle Cell Lymphoma
255. 84 F. A mass within the left low lobe of lung

Lymphoplasmacytic Lymphoma / Waldenström's Macroglobulinemia

254. 33 M. Axillary lymph node Anaplastic Large Cell Lymphoma, ALK+
253. 34 M. 3rd degree burn. Peripheral blood smear

Thermal Injury

252. 57 M. Marked leukocytosis. Bone marrow biopsy Chronic Myelogenous Leukemia
251. 44 F. Cervical lymph node Classic Hodgkin Lymphoma, Lymphocyte Depletion Subtype
250. 45 F. A large cervical lymph node Follicular  Dendritic Cell Sarcoma
249. 52 M. A large inguinal lymph node Interdigitating Dendritic Cell Sarcoma
248. 43 M. An abdominal wall soft tissue mass Rosai-Dorfman Disease of Soft Tissue
247. 55 F. A dura based brain lesion Histiocytic Sarcoma
246. 3 M. Cytopenia and hepatosplenomegaly. Bone marrow biopsy Gaucher Disease
245. 16 M. A large cervical lymph node Metastatic Undifferentiated Nasopharyngeal Carcinoma
244. 45 M. A large cervical lymph node Classic Hodgkin Lymphoma, Syncitial Variant
243. 38 M. Peripheral blood smear Acute myeloid leukemia with t(15;17)
242. 63 M. A 6.0cm inguinal lymph node Nodal Merkel Cell Carcinoma
241. 46 F. Pancytopenia. Bone marrow biopsy Metastatic lobular carcinoma of breast in bone marrow
240. 47 M. Excisional skin biopsy Granulomatous mycosis fungoides
239. 57 M. Lymphadenopathy. Bone marrow biopsy Diffuse Large B-Cell Lymphoma Involving Bone Marrow
238. 32 F. Bone marrow biopsy Acute Myeloid Leukemia With Inv16 or t(16;16)
237. 49 F. Biopsy of breast implant capsule Implant-related primary anaplastic large cell lymphoma (ALCL) of the breast
236. 55 M. Bone marrow biopsy

Plasma Cell Myeloma

235. 61 M. Bone marrow biopsy Acute Myeloid Leukemia with t(8;21)(q22;q22)
234. 62 M. History of skin lesion. Bone marrow biopsy Blastic Plasmacytoid Dendritic Cell Neoplasm
233. 37 M. Lymphadenopathy. Bone marrow biopsy Bone marrow involvement by anaplastic large cell lymphoma
232. 34 M. Bone marrow biopsy Acute Myeloid Leukemia With Inv16 or t(16;16)
231. 49 F. A 2.7 cm breast mass lesion Plasmacytoma of breast
230. 35 F. A 3.3 cm cervical lymph node Classic Hodgkin Lymphoma, Mixed Cellularity Type, Histiocyte-Rich Variant
229. 61 M. An enlarged inguinal lymph node

Peripheral T-Cell lymphoma, Lymphoepithelioid Variant (Lennert Lymphoma)

228. 53 F. Large cervical lymph node. Follicular Lymphoma with Signet-Ring Tumor cells
227. 11 M. A 4 cm cecal mass. Burkitt Lymphoma
226. 43 M. Inguinal lymph nodes Follicular Lymphoma with Sclerosis
225. 18 M. Cervical lymph node biopsy Classic Hodgkin Lymphoma, Mixed Cellularity Type
224. 69 F. Marked macrocytic anemia. Bone marrow biopsy Megaloblastic Anemia
223. 48 F. Bone marrow biopsy Plasma Cell Myeloma
222. 61 F. Enlarged inguinal lymph node Follicular Lymphoma with Marginal Zone Differentiation
221. 56 M. Bone marrow biopsy Plasma Cell Myeloma  with Intracytoplasmic Crystals
220. 15 M. Atypical cells in the peripheral blood smear B-Cell Acute Lymphoblastic Leukemia
219. 56 M. Bone marrow biopsy Plasma Cell Myeloma
218. 42 M. Right axillary lymphadenopathy Nodular Lymphocyte Predominant Hodgkin Lymphoma
217. 69 M. Pancytopenia and splenomegaly. Bone marrow biopsy Hairy Cell Leukemia
216. 61 F. Marked lymphocytosis and splenomegaly. Bone marrow biopsy B-Cell Prolymphocytic Leukemia
215. 34 F. Cervical lymphadenopathy Anaplastic Large Cell Lymphoma
214. 81 M. Marked leukocytosis. Blood smear Chronic lymphocytic Leukemia
213. 43 F. Axillary lymph nodes

Plasmacytoid dendritic cell nodule

212. 52 F. Lymphadenopathy and leukocytosis. Blood smear Circulating Follicular Lymphoma Cells in Peripheral Blood
211. 59 M. Peripheral blood smear Circulating Sezary Cells in Peripheral Blood
210. 68 M. Peripheral blood smear Circulating Sezary Cells in Peripheral Blood
209. 71 F. Lymphadenopathy and leukocytosis. Blood smear Circulating Mantle Cell Lymphoma Cells in Peripheral Blood
208. 66 M. Leukocytosis, hepatosplenomegaly, and lymphadenopathy T-Cell Prolymphocytic Leukemia (T-PLL)
207. 65 M. Peripheral blood smear Plasma Cell Leukemia
206. 49 F. Systemic lymphadenopathy and leukocytosis. Blood smear Circulating Follicular Lymphoma Cells in Peripheral Blood
205. 71 M. Bone marrow biopsy Plasma Cell Myeloma
204. 66 M. Bone marrow biopsy Plasma Cell Myeloma
203. 59 F. Lymphadenopathy. Bone marrow biopsy Classic Hodgkin Lymphoma Involving Bone Marrow
202. 41 M. A humerus bone lesion Langerhans Cell Histiocytosis
201. 74 M. Leukocytosis, hepatosplenomegaly, and lymphadenopathy T-Cell Prolymphocytic Leukemia (T-PLL)
200. 54 M. HIV+, systemic lymphadenopathy Castleman disease, multicentric
199. 9 M. Fever and sore throat with enlarged bilateral tonsils Acute infectious mononucleosis of tonsils
198. 13 M. An enlarge cervical lymph node Kimura disease, nodal
197. 37 F. Cervical lymph node Systemic lupus erythematosus (SLE) lymphadenopathy
196. 39 F. An enlarged left cervical lymph node Kikuchi-Fujimoto lymphadenitis
195. 29 F. Cervical lymphadenopathy Toxoplasmosis lymphadenopathy
194. 64 M. Skin lesion on the back Classic Hodgkin lymphoma, primary cutaneous
193. 46 F. A lip mucosal nodule Extranodal marginal zone lymphoma, MALT type
192. 60 F. An enlarged cervical lymph node Systemic mastocytosis involving lymph node
191. 34 M. An enlarged inguinal lymph node Anaplastic large cell lymphoma, nodal
190. 41 F. Multiple skin lesions Systemic mastocytosis
189. 67 M. Lung lesions Lymphomatoid granulomatosis of lung
188. 73 M. Cervical lymphadenopathy

Plasma Cell Myeloma Involving Lymph Node

187. 68 M. Splenomegaly

Plasma Cell Myeloma Involving Spleen

186. 1-year-old male. Pancytopenia and hepatosplenomegaly

Niemann-Pick Disease

185. 41 M. HIV+, oral lesion

Plasmablastic Lymphoma of Oral Cavity

184. 61 M. Brain lesion Primary CNS lymphoma
183. 56 F. Pathologic fracture of the femur Rosai-Dorfman Disease of Bone
182. 58 M. Obturator lymph nodes

Metallosis of Lymph node

181. 38 M. Soft tissue mass of chest wall Rosai-Dorfman Disease
180. 72 M. Mediastinal lymph node biopsy and bone marrow biopsy

ALK Positive Large B-Cell Lymphoma

179. 67 F. Mesenteric lymphadenopathy with colonic mass lesions

Sinusoidal CD30+ Large B-Cell Lymphoma

178. 52 M. Multiple enlarge cervical lymph nodes

Classic Hodgkin Lymphoma, Mixed Cellularity Subtype

177. 72 M. Blood clots from  a dissecting aortic aneurysm Diffuse large B-cell lymphoma
176. 47 M. Mesenteric lymphadenopathy T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
175. 56 F. A cecal polyp with mesenteric lymphadenopathy Diffuse large B-cell lymphoma
174. 49 F. History of breast implant. A breast mass Metastatic Melanoma
173. 61 M. Bone marrow biopsy

Systemic mastocytosis

172. 42 F. Cervical lymphadenopathy

Classic Hodgkin Lymphoma, Lymphocyte Depletion Type

171. 46 F. Cervical lymphadenopathy

Metastatic Thyroid Medullary Carcinoma

170. 34 M. HIV+, gastric lesion and systemic lymphadenopathy Large B-cell lymphoma
169. 36 M. HIV+, inguinal lymphadenopathy Vascular proliferation
168. 56 F. Ovarian mass Diffuse large B-cell lymphoma
167. 47 F. Anterior mediastinal mass

Classic Hodgkin Lymphoma in Lymphoepithelial Cyst

166. 65 M. Neck abscess and cervical lymphadenopathy Necrotizing granulomas
165. 66 F. Axillary lymph node dissection for breast carcinoma Mantle Zone Hyperplasia
164. 56 F. Colectomy for Crohn's disease. Mesenteric lymph nodes Granulomas in lymph node
163. 74 M. Multiple enlarged cervical lymph nodes SLL with large B-cell transformation and metastatic squamous cell carcinoma
162. 17 M. Cervical lymphadenopathy Rosai-Dorfman disease
161. 55 F. Axillary lymph node dissection for breast carcinoma Benign Mammary Glandular Inclusions in Lymph Node
160. 16 M. HIV+. Cervical lymphadenopathy Extracavitary HHV8 associated large B-cell lymphoma
159. 44 F. Axillary lymphadenopathy Metastatic lobular carcinoma of breast in lymph node
158. 44 F. A cystic lesion in the spleen ?
157. 39 M. Splenectomy due to trauma Marginal Zone Hyperplasia
156. 34 M. Splenectomy due to trauma Amyloidosis of Spleen
155. 24 F. Axillary lymph node dissection for breast cancer Mantle zone hyperplasia of lymph node
154. 45 M. Brain lesion Myeloid sarcoma in brain
153. 5-hour-old neonate. Abnormal CBC and peripheral blood smear Transient Abnormal Myelopoiesis (TAM) of neonate
152. 23 M. Enlarged cervical lymph nodes Atrophy of Lymph Node due to Sickle Cell Disease
151. 39 F. Splenomegaly (2,568 grams) and lymphadenopathy Extramedullary Hematopoiesis
150. 55 F. Axillary lymphadenopathy. Metastatic Lobular Carcinoma of Breast
149. 45 F. Incidental finding in axillary lymph node Intranodal melanocytic nevocellular inclusions (nodal nevi)
148. 37 M. HIV+. Colon lesion and mesenteric lymphadenopathy Extracavitary HHV8 associated large B-cell lymphoma
147. 59 F. Cervical lymphadenopathy Atypical lymphohistiocytic proliferation
146. 28 M. Nasal lesion Nasal NK/T cell lymphoma
145. 33 F. A 3.9 cm periportal lymph node T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
144. 66 F. A 3.2 × 3.0 cm right axillary lymph node Castleman disease, hyaline vascular type
143. 30 M. HIV+. Generalized lymphadenopathy HIV lymphadenitis, chronic phase
142. 27 M. HIV+. Generalized lymphadenopathy HIV lymphadenitis, acute phase
141. 62 M. An enlarged obturator lymph node Metallosis of lymph node
140. 61 m. Cervical lymphadenopathy Myeloid sarcoma involving lymph node
139. 53 M. Inguinal lymphadenopathy Marginal zone lymphoma with follicular colonization
138. 51 F. Thyroid lesion Diffuse large B-cell lymphoma of thyroid
137. 60 F. Splenomegaly and lymphadenopathy Mantle cell lymphoma
136. 36 F. Inguinal lymphadenopathy Peripheral T-cell lymphoma involving lymph node
135. 45 F. Axillary lymphadenopathy Peripheral T-cell lymphoma involving lymph node
134. 45 F. Multiple nodular lesions in spleen Littoral cell hemangioma
133. 32 M. HIV+, cervical lymphadenopathy Mycobacterium avium complex (MAC)
132. 45 M. Severe anemia and leukopenia. Bone marrow biopsy Marrow changes in copper deficiency 
131. 64 M. Peripheral blood smear Plasma Cell Leukemia, IgA type, with Flame Cells
130. 37 M. Soft tissue mass in arm Kimura Disease
129. 24 M. Cervical lymphadenopathy and splenomegaly Lymphadenopathy associated with infectious mononucleosis
128. 80 F. Orbital mass Mantle Cell Lymphoma
127. 47 F. Axillary lymphadenopathy Peipheral T-cell lymphoma involving lymph node
126. 33 F. Inguinal lymphadenopathy Cat scratch disease of lymph node
125. 28 F. Axillary lymphadenopathy Cat scratch disease of lymph node
124. 77 M. Severe anemia. Bone marrow biopsy Parvovirus infection of erythroid cells in bone marrow
123. 5 M. Ocular lesion Myeloid sarcoma, monoblastic
122. 56 F. Multiple skin lesions NK/T cell lymphoma v.s. blastic plasmacytoid dendritic cell neoplasm
121. 48 M. Cervical lymphadenopathy Peripheral T-Cell lymphoma, Lymphoepithelioid Variant (Lennert Lymphoma)
120. 45 F. Bone marrow biopsy Systemic mastocytosis
119. 51 F. Enlarged inguinal lymph node Palisaded Myofibroblastoma
118. 58 M. Proximal humerus bone lesion Large B-cell lymphoma
117. 37 F. Enlarged cervical lymph node Anaplastic large cell lymphoma, ALK1+
116. 46 F. Multiple skin lesions Primary Cutaneous CD30+ Lymphoproliferative Disorder
115. 46 F. Bilateral cervical lymphadenopathy Toxoplasma lymphadenitis
114. 58 M. Testicular mass Large B-cell lymphoma
113. 55 F. Enlarged submandibular lymph node Large B-cell lymphoma
112. 66 M. Renal mass Follicular lymphoma
111. 62 M. BCG treatment for urothelial carcinoma. Bone marrow biopsy BCG Granuloma in Bone Marrow
110. 65 F. Scalp skin lesion Follicular lymphoma, primary or metastatic
109. 65 F. Cervical lymphadenopathy Alveolar rhabdomyosarcoma, metastatic 
108. 65 M. History of CLL with anemia and fever. Bone marrow biopsy. Histoplasmosis
107. 63 M. Peripheral blood smear and CSF Mantle Cell Lymphoma
106. 68 F. Massive splenomegaly Splenic Marginal Zone Lymphoma
105. 37 M. Hepatosplenomegaly Hepatosplenic Gamma-Delta T-Cell Lymphoma 
104. 63 M. Gastric biopsy Mantle Cell Lymphoma
103. 9 M. Cervical lymphadenopathy Rosai-Dorfman Disease
102. 45 M. Testicular mass Rosai-Dorfman Disease
101. 56 M. Pancytopenia and bone pain. Bone marrow biopsy Burkitt Lymphoma
100. 75 M. Systemic lymphadenopathy and multiple organ involvement Classic Hodgkin Lymphoma
99. 3 M. An ileocecal mass Burkitt lymphoma
98. 5 M. A cecal mass and enlarged mesenteric lymph nodes Burkitt lymphoma
97. 4 F. Bone marrow biopsy Metastatic neuroblastoma in the bone marrow
96. 10 M. Splenomegaly, thrombocytopenia and leukopenia Gaucher's disease in bone marrow
95. 7 M. A large mediastinal mass T-cell lymphoblastic lymphoma
94. 5 weeks old female. Abnormal CBC and blood smear Acute megakaryoblastic leukemia with t(1;22)
93. 16 F. Atypical lymphocytosis of peripheral blood Infectious mononucleosis
92. 6 F. An enlarged left neck lymph node T-cell lymphoblastic lymphoma
91. 4 M. Enlarged mesenteric lymph nodes Burkitt lymphoma
90. 16 F. An enlarged left postauricular lymph node Anaplastic large cell lymphoma, lymphohistiocytic variant
89. 11 F. A mass in the occipital skull Langerhans cell histiocytosis
88. 61 M. Right cervical lymph nodes Small lymphocytic lymphoma
87. 67 M. Atypical lymphocytosis in peripheral blood Mantle cell lymphoma cells in peripheral blood
86. 41 F. HIV+ with abdominal lymphadenopathy Castleman disease
85. 57 M. Axillary lymphadenopathy Marginal zone lymphoma, primary nodal
84. 44 M. Axillary lymphadenopathy Lymphadenopathy associated with tattoo
83. 65 M. Colon mass Diffuse Large B-cell lymphoma of the colon
82. 65 M. Splenomegaly and lymphadenopathy Myeloid sarcoma in lymph node
81. 65 M. Bone marrow biopsy Acute myeloid leukemia
80. 66 M. Bilateral inguinal lymphadenopathy Diffuse large B-cell lymphoma, transformed from follicular lymphoma
79. 65 M. HIV+ and left inguinal lymphadenopathy Myeloid sarcoma in lymph node
78. 75 M. A T5 epidural mass Diffuse large B-cell lymphoma
77. 45 M. A 5 cm pancreatic mass Myeloid sarcoma of pancreas
76.

58 M. Cervical lymph node

Classic Hodgkin lymphoma
75.

62 F. Minor salivary gland lesion

Extranodal marginal zone lymphoma (MALT Lymphoma)
74.

65 M. Inguinal lymph node

Mantle cell lymphoma
73.

70 M. Inguinal lymph node

Merkel cell carcinoma of lymph node
72.

69 F. Skin lesion

Primary cutaneous follicle center lymphoma
71.

56 M. Rectal mass

Mantle cell lymphoma
70.

66 M, h/o CLL/SLL. Cervical lymph node

Diffuse large B-cell lymphoma transformed from CLL (Richter’s transformation)
69.

27 F. Cervical lymph node

Classic Hodgkin Lymphoma, nodular sclerosis type, syncitial variant

68.

27 M. Inguinal lymph node

Nodular lymphocyte predominant Hodgkin lymphoma

67.

61 F. Bone marrow

Systemic mastocytosis
66.

50 M. Serum protein electrophoresis

Light chain myeloma
65.

39 M. Bone marrow

Metastatic angiosarcoma to the bone marrow
64.

18 F, h/o anemia and splenomegaly. Peripheral blood smear

β-Thalassemia
63.

17 M, anemia. Peripheral blood smear

Hereditary elliptocytosis
62.

11 M, soft tissue mass from right upper arm

Kimura disease
61.

62 M, a small intestinal mass

Follicular lymphoma, low grade
60.

58 F, right axillary lymph node

Diffuse large B-cell lymphoma
59.

59 F, left axillary lymph node

Angioimmunoblastic T-cell lymphoma
58.

80 F, right axillary lymph node

Metastatic desmoplastic melanoma
57.

28 F, right medial thigh skin lesion

Cutaneous mastocytosis
56.

37 F, right neck lymph node

Classic Hodgkin lymphoma, nodular sclerosis subtype
55.

24 F, an incidental anterior mediastinal mass

Castleman disease, hyaline vascular subtype
54.

38 F, liver lesion

Systemic mastocytosis
53.

54 M, inguinal lymph node

Peripheral T-cell lymphoma, nodal
52.

72 M, a small intestinal mass

Extra nodal marginal zone lymphoma
51.

47 F, history of Castleman disease. Mediastinal lymph node

Follicular dendritic cell sarcoma
50.

68 M, a solitary cutaneous nodule

Primary cutaneous anaplastic large cell lymphoma
49.

39 F, gallbladder

Systemic mastocytosis
48.

57 F, enlarged mesenteric lymph nodes

Diffuse large B-cell lymphoma, CD30+
47.

33 M, subcutaneous soft tissue mass

Anaplastic large cell lymphoma, small cell variant
46.

44 F, generalized lymphadenopathy. Cervical lymph node

Sarcoidosis and asteroid body
45.

43 F, marked leukocytosis. Peripheral blood smear

Acute myeloid leukemia
44.

49 F, history of splenectomy. Peripheral blood smear

Basophilic stippling and Howell-Jolly bodies
43.

77 M, left supraclavicular lymph node

Granular cell sarcoma (Myeloid sarcoma)
42.

58 M, history of CLL and gastroesophageal mass. Bone marrow

Plasmablastic lymphoma directly transformed from CLL/SLL
41.

58 M, history of CLL. Gastroesophageal mass

Plasmablastic lymphoma directly transformed from CLL/SLL
40. 45 F, history of splenectomy. Peripheral blood Howell-Jolly bodies
39. 50 F, left cervical lymph node Classic Hodgkin lymphoma, nodular sclerosis subtype
38. 29 M, right submandibular lymph node Nodular lymphocyte predominant Hodgkin lymphoma
37. 18 F, right thyroid lesion Classic Hodgkin lymphoma, nodular sclerosis subtype
36. 58 M, right axillary lymph node Chronic lymphocytic leukemia/small lymphocytic lymphoma
35. 60 M, retroperitoneal lymph node Nodal marginal zone lymphoma
34. 66 M, right testicular mass Primary testicular large B-cell lymphoma
33. 56 M, mediastinal lymph node Follicular lymphoma
32. 80 F, right axillary lymph node Angioimmunoblastic T-cell lymphoma
31. 15 M, anemia and abnormal RBC shapes. Peripheral blood Hereditary elliptocytosis
30. 63 M, lymphocytosis

Large granular lymphocytic leukemia

29. 59 M, nasal mass biopsy Diffuse large B-cell lymphoma of nasal cavity
28. 53 M, splenomegaly Diffuse large B-cell lymphoma of spleen
27. 58 M, skin lesions and systemic lymphadenopathy. Anaplastic large cell lymphoma, ALK-, involving lymph node and skin
26. 74 M, pancytopenia. Bone marrow biopsy Metastatic prostatic carcinoma
25. 11 M, axillary lymph node Anaplastic large cell lymphoma, ALK+, lymphohistiocytic variant
24. 44 M. Bone marrow biopsy Acute myeloid leukemia
23. 54 M. Bone marrow biopsy Acute promyelocytic leukemia, hypergranular type
22. 55 M, small intestine mass Entropathy-associated T-cell lymphoma (EATL), type II
21. 47 M, left inguinal lymph node Mantle cell lymphoma

20.

71 M, inguinal lymph node

Anaplastic Large Cell Lymphoma, ALK-

19.

11 M, marked leukocytosis. Peripheral blood

Acute myeloid leukemia with monocytic differentiation

18.

81 M, multiple lytic bone lesions. Bone marrow biopsy

Plasma cell myeloma, with plasmablastic features

17.

73 M, h/o myelodysplasia. Peripheral blood

Chronic myelomonocytic leukemia (CMML)

16.

48 F, vulva lesion

Langerhans cell histiocytosis of the vulva

15.

52 M, h/o CLL, splenic hilar lymph node

Hodgkin lymphoma, transformed from CLL/SLL, Richter’s transformation

14.

39 M, supraclavicular lymph node

Nodular lymphocyte predominant Hodgkin lymphoma

13.

78 M, leukocytosis. Bone marrow biopsy

Acute myeloid leukemia with monocytic differentiation and t(8;22)

12.

57 M, multiple small colonic polyps

Mantle cell lymphoma, presented as lymphomatoid polyposis

11.

36 M, inguinal lymph node

Anaplastic Large Cell Lymphoma, ALK-

10.

52 M, severe anemia. Bone marrow biopsy

Myelodysplastic syndrome with t(3;9)(q22;p24)

9.

67 F, marked lymphocytosis and splenomegaly. Peripheral blood

B-cell prolymphocytic leukemia

8.

66 M, lymphocytosis. Peripheral blood

Chronic lymphocytic leukemia

7.

32 F, Fever, superficial lymphadenopathy

Kikuchi-Fujimoto lymphadenitis (histiocytic necrotizing lymphadenitis)

6.

56 M, h/o CML. Bone marrow biopsy

Acute lymphoblastic leukemia, transformed from CML

5.

77 M, h/o MGUS. Bone marrow biopsy

Plasma cell myeloma

4.

24 M, pancytopenia. Bone marrow biopsy

Acute promyelocytic leukemia, hypergranular type

3.

51 F, right cervical lymphadenopathy

Classic Hodgkin lymphoma, lymphocyte-rich subtype, nodular variant

2.

49 M, leukocytosis. Bone marrow biopsy

Acute promyelocytic leukemia, hypogranular type

1.

51 F, SLE and anemia. Bone marrow biopsy

Lupus Erythematosus cell (LE Cell)