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Case 15 - Discussion

Surgical Pathology Case


CMV, IPX, 20 CMV, IPX,, 40
CMV, IPX,, 60 CMV, IPX,, 40

CMV Pneumonia

  • In immunocompetent individuals, most CMV infections are mild and may only produce a viral syndrome resembling infectious mononucleosis

  • CMV is the most common infection in solid organ transplants, with over half of the patients showing evidence of active CMV infection

  • The white cells in ~ 5% of blood donors contain CMV, therefore infection by blood transfusion occurs in a large number (60%) of patients

  • CMV can infect epithelial cells of the airways and alveoli, fibroblasts, macrophages and endothelial cells.  The infected cells show both intranuclear and intracytoplasmic inclusions. The characteristic  intranuclear inclusions are bright eosinophilic with a bull-eye appearance and a clear perinuclear halo