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Case 36 - Discussion

Surgical Pathology Case

CK 5/6,  20 EGFR, 20
 
CD14, 20  
Actin, 20, tumor Actin, 20, normal ducts in the same case
Caldesmon, 20, tumor Caldesmon, 20, normal ducts in the same case
Desmin, 20, tumor Desmin, 20, normal ducts in the same case
Myogenin, 20, tumor Myogenin, 20, Positive control
p63, 20, tumor p63, 20, normal ducts in the same case
SMM, 20, tumor SMM, 20, normal ducts in the same case
SMA, 20, tumor SMA, 20, normal ducts in the same case
   

 

Diagnosis: Infiltrating ductal carcinoma, basaloid subtype
 
Immunohistochemistry Stains:
ER		Negative
PR		Negative
Her2/Neu	Borderline
Ki-67		Positive
CK5/6		Focally positive
CK14		Positive
EGFR		Positive
Smooth muscle/myoepithelium markers:
Actin		postive
Caldesmon	weakly positive
Desmin		focally positive
Myogenin	weakly positive
p63		focally weakly positive
SMM		positive
SMA		positive
HER2/neu is not amplified by FISH.