Case 57 - Discussion

Uploaded: 2007-06-11, Updated: 2007-06-24

EM EM
EM EM
EM EM
EM EM
   

CK 5/6 WT1
   
 

Immunohistochemistry:

The tumor cells are positive for calretinin, WT-1, and weak CK5/6, but are negative for S-100 and HMB-45. The tumor cells do not stain with mucicarmine. 

     

Electron microscopy:

The tumor consist of sheets of round, oval or short-spindle cells with a moderate amount of cytoplasm.  Inter-cellular junctions are noted.  The tumor cells have long, thin surface microvilli (length-to-diameter greater than 10:1) which are free of glyocalyx.  The cytoplasm contains moderate to abundant round mitochondria and some rough endoplasm reticulum. No other organelles are prominent.  The nuclei are round to oval, with numerous clefts, and single prominent nucleoli. 

Ultrastructural Impression:  Malignant Mesothelioma