Case 101 - Discussion

 

 

Bullous pemphigoid

  • Intertriginous areas of trunk, 1/3 mucosal involvement
  • Antigens: BPAg1 (230 kD), BPAg2 (180 kD)
  • Gross: tense bullae, erythematous papules
  • HE:
    • Subepidermal blister
    • Infiltration with polymorphous
    • Eosinophil predominant
  • DIF: IgG, C3, linear, dermal-epidermal junction