Case 115 - Discussion

Uploaded: 2007-09-29, Updated: 2007-09-29

 

 

   

METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE

Microscopically the tumor is well demarcated and consists of large polygonal cells  that are arranged in tubular-glandular or nested patterns.  The tumor is vascular and the majority of the tumor cells have abundant clear cytoplasm with one small- to medium-sized nucleus. Some of the tumor cells have fine granular eosinophilic cytoplasm. The tumor cells are strongly positive for vimentin and CD10, but negative for RCC, CD117 and TTF-1.  Colloidal iron staining is negative. The histologic features and immunoprofile support a diagnosis of metastatic renal cell carcinoma