Updated: 01/2011                                 

  EDUCATION BACKGROUND

07/2011 – 06/2012

Fellowship Training, Hematopathology

     07/2010 – 06/2011

Fellowship Training, General Surgical Pathology

Department of Pathology, University of Alabama at Birmingham

Birmingham, Alabama, USA

     07/2006 – 06/2010

Residency Training, Anatomic and Clinical Pathology

Department of Pathology, Creighton University Medical Center

Omaha, Nebraska, USA

    08/2000 – 06/2006

Doctor of Philosophy (PhD)

Advisor: Dr. Wing-Chung (John) Chan

Center for Leukemia and Lymphoma Research

Department of Pathology and Microbiology

University of Nebraska Medical Center, Omaha, Nebraska, USA

    08/1997 – 07/2000

Pathology Resident, Teaching Assistant, Lymphoma Research and Diagnosis

Advisor: Dr. Zifen Gao

Laboratory for Lymphoma Diagnosis and Research

Department of Pathology

Peking University Health Science Center (Beijing Medical University)

    02/1996 – 07/1997

Elective Rotation for Lymphoma Research

Advisor: Dr. Zifen Gao

Laboratory for Lymphoma Diagnosis and Research

Department of Pathology

Peking University Health Science Center (Beijing Medical University)

    08/1992 – 07/1997

Bachelor of Medicine (MD)

Peking University Health Science Center (Beijing Medical University)

Beijing, China

  RESEARCH PROJECTS (CURRENT AND PAST)

   1.  2009 Resident Research Grant Award from CAP Foundation (10/01/2009 – 11/01/2010)

 Title of Project: GCET2 Expression in Acute Lymphoblastic Leukemia/Lymphoma

Principle investigator: Zenggang Pan, MD, PhD. Faculty Supervisor: Hina Nashaud, MD

Summary: GCET2/HGAL is one of several germinal center (GC) B-cell genes that I cloned during my PhD training. It is a membrane adaptor that, upon B-cell activation, recruits cytoplasmic proteins to the cell membrane to form a signal transducing scaffold. GCET2 is one of the top markers for normal GC B-cell and GC B-cell derived lymphomas. We also found that GCET2 mRNA is highly expressed in the thymus and immature B-cell lines. The major purpose of this study is to investigate GCET2 protein expression in clinical cases of acute lymphoblastic leukemia/lymphoma, and the protein expression will be correlated with clinical behaviors, cytogenetic aberrances, and prognoses in the clinical samples.

   2. Virtual Karyotyping of Chronic Lymphocytic Leukemia (CLL) by SNP Array

Advisor: Dr. Jill Hagenkord

Summary: SNP arrays provide a high-resolution “virtual karyotype”. Our data have shown that SNP array is more sensitive in detecting genomic aberrances in CLL than conventional karyotyping and FISH. This project specifically focuses on subclassification of del(13q14) and copy neutral loss-of-heterozygosity of 17p (CN-LOH 17p). Del(13q14) is heterogeneous and  can be subclassified based on length of deletion and deletion of single or double alleles. The subtypes of del(13q14) are associated with different clinical behaviors of CLL. CN-LOH is important in tumor pathogenesis, in which the tumor may acquire two mutated alleles of a gene from one parent.

   3. Classification of Diffuse Large B-Cell Lymphoma Using the New Algorithm (Current)

Co-investigator: Drs. Min Li, Wing-Chung (John) Chan. Zifen Gao

Summary: Diffuse large B-cell lymphoma (DLBCL) can be divided into two major subgroups by gene expression profiling, germinal center B-cell-like (GCB), and activated B-cell-like (ABC). GCB-DLBCL has a significantly better prognosis than the ABC group. Recently a new algorithm was proposed using five antibodies (GCET1, CD10, BCL6, MUM1 and FOXP1) to classify DLBCL into GCB and non-GCB subgroups, which showed higher sensitivity and specificity than the previous Hans algorithm.

   4. Thymidylate Synthetase Expression, Genotype and Classification in Pseudomyxoma Peritonei  (2007)

Advisors: Dr. Poonam Sharma and Dr. Zoran Gatalica

Summary: Pseudomyxoma peritonei (PMP) is characterized by peritoneal spread of a mucinous neoplasm, most commonly of appendiceal origin, and massive accumulation of mucin in the abdomen. PMP has two histologic and clinical subtypes: low grade (disseminated peritoneal adenomucinosis, DPAM), and high grade (peritoneal mucinous carcinomatosis, PMCA). We evaluated the expression of thymidylate synthase (TS) in PMP and its correlation with tumor grade, proliferative fraction and expression of p53. We concluded that TS expression is significantly higher in high grade PMP than in low grade PMP, and TS expression correlates with p53 and especially Ki67. These findings are consistent with the TS data on colorectal cancers

   5. Cloning of Germinal Center B-Cell Associated Genes, GCET1 and GCET2 (2000-2006, PhD thesis)

Advisor: Dr. Wing-Chung (John) Chan

Summary: DLBCL has been divided into two major subgroups by gene expression profiling, GCB and ABC. Many genes in the GCB-DLBCL have not been cloned and are represented as short expressed sequence tags (ESTs). The goal of my PhD thesis was to clone and characterize several GC B-cell associated genes from selected top ESTs in the GCB-DLBCL. Two new genes, GCET1/Centerin and GCET2/HGAL, were cloned using the rapid amplification of cDNA end (RACE) technique. Both GCET1 and GCET2 are among the top markers of normal germinal center (GC) B-cells and GC B-cell derived lymphomas. GCET1 belongs to the SERPIN family. GCET2 is a membrane adapter that can be phosphorylated by protein tyrosine kinase, Lyn and Syk. Phosphorylated GCET2 recruits cytoplasmic SH2 proteins to cytoplasmic membrane to form a signal transducing scaffold.

   6. Classification of Diffuse Large B-Cell Lymphoma (2003)

Key investigators: Dr. Christine P Hans and Dr. Wing-Chung (John) Chan

Summary: In the project, an immunohistochemical stain algorithm (the Hans algorithm) with three antibodies (CD10, BCL6 and MUM1) was used to classify DLBCLs into GCB and non-GCB subtypes. It resulted in ~ 80% concordance with gene expressing profiling.

  7. Clinicopathologic Features, Immunophenotype and Epstein-Barr virus in Nasopharyngeal Lymphoma

       (1996-1997, medical school thesis project)

Advisor: Dr. Zifen Gao

Summary: 112 cases of primary nasopharyngeal lymphoma from Northern China were colleted to study the clinicopathologic features, immunophenotype and Epstein-Barr virus (EBV) infection of these cases. 77/112 cases (68.8%) were T-cell lymphomas, and 35 cases (31.2%) were B cell lymphomas. EBV infection was identified in 54/101 (53.5%) cases, including 48 T-cell lymphomas and 6 B-cell lymphoma, by EBER in situ hybridization.

  PUBLICATIONS AND PRESENTATIONS

  PEER REVIEWED RESEARCH ARTICLES

▪ Zenggang Pan, Yulei Shen, Baosheng Ge, Cheng Du, Timothy McKeithan, Wing C Chan. Studies of a Germinal Center B-cell Expressed Gene, GCET2, Suggest its Role as a Membrane Associated Adapter Protein.  British Journal of Hematology. 2007 June; 137(6):578-590.

▪ Christine P Hans, Dennis D Weisenburger, Timothy C Greiner, Wing C Chan, Patricia Aoun, Gregory T Cochran, Zenggang Pan, Lynette M Smith, James C Lynch, Robert Gregory Bociek, Philip J Bierman, Julie M Vose and James O Armitage. Expression of PKC-beta or Cyclin D2 Predicts for Inferior Survival in Diffuse Large B-Cell Lymphoma. Modern Pathology. 2005 October; 18(10):1377-1384.

▪ Christine P. Hans, Dennis D. Weisenburger, Timothy C. Greiner, Randy D. Gascoyne, Jan Delabie, German Ott, H. Konrad Müller-Hermelink, Elias Campo, Rita M. Braziel, Elaine S. Jaffe, Zenggang Pan, Pedro Farinha, Lynette M. Smith, Brunangelo Falini, Alison H. Banham, Andreas Rosenwald, Louis M. Staudt, Joseph M. Connors, James O. Armitage, and Wing C. Chan. Confirmation of the Molecular Classification of Diffuse Large B-Cell Lymphoma by Immunohistochemistry Using a Tissue Microarray. Blood. 2004 January 1; 103(1):275-282.

▪ Zenggang Pan, Yulei Shen, Cheng Du, Guimei Zhou, Andreas Rosenwald, Louis M. Staudt, Timothy C. Greiner, Timothy W. McKeithan and Wing C. Chan. Two Newly Characterized Germinal Center B-Cell Associated Genes, GCET1 and GCET2, Have Differential Expression in Normal and Neoplastic B-cells. The American Journal of Pathology. 2003 July; 163(1):135-144.

▪ Zifen Gao, Fen Jiang, Zenggang Pan. P53 Gene Mutation and EBV Associated Nasopharyngeal T-Cell Lymphoma. Chinese Journal of Clinical Oncology. 1999 November; 26(6); 429-432.

▪ Zifen Gao, Faith Ho, Zenggang Pan. Comparative Studies of Nasopharyngeal B-Cell Lymphomas in Hong Kong and Beijing. Journal of Beijing Medical University. 1999 February; 31(2):42-44.

▪ Zifen Gao, Honghai Wang, Zenggang Pan. Investigation of the Clinicopathologic Features, Immunophenotype and Epstein - Barr virus Infection of the Upper Respiratory Tract Lymphomas. The Chinese Journal of Pathology. 1998 August; 27(4):251-254.

  PEER REVIEWED CASE STUDIES

▪ Zenggang Pan, Susan Repertinger, Caishu Deng, Wing C. Chan, Qingmei Xie. Plasmablastic Lymphoma Transformed from Chronic Lymphocytic Leukemia with a Newly Acquired C-Myc Gene Rearrangement. Journal of Clinical Oncology. (Submitted)

▪ Zenggang Pan, Susan Repertinger, Ronald Leonard, Poonam Sharma, Zoran Gatalica and Chhanda Bewtra. Two Cases of Metastatic Appendiceal Goblet Cell Carcinoma Mimicking Primary Uterine Cervical and Endometrial Adenocarcinomas. The Archives of Pathology & Laboratory Medicine. 2010;134:776–780

▪ Zenggang Pan, Michael H. McGuire, Warren G. Sanger, Julia A. Bridge, and William J. Hunter. A (6;13)(q15;q34) Translocation in a Reparative Granuloma of the Bone: a Case Report and Review of the Literature. Cancer Genetics and Cytogenetics. (Revising, 08/2009)

▪ Zenggang Pan, Sanjeev Sharma, Poonam Sharma. Primary Langerhans' Cell Histiocytosis of the Vulva: A Rare Disease in an Unusual Location. Indian Journal of Pathology and Microbiology. 2009, January. 52 (1): 65-68. (PMID: 19136785)

▪ Zenggang Pan, Poonam Sharma, Susan Repertinger, Caishu Deng. A Giant Cystic Pheochromocytoma from the Adrenal Gland. Endocrine Pathology. 2008 March 6. (PMID: 18322657)

▪ Zenggang Pan, Daniel Albertson, Amardip Bhuller, Bo Wang, James M Shehan, and Deba P Sarma. An Angiosarcoma of the Scalp Mimicking a Sebaceous Cyst. Dermatology Online Journal. 2008, 14 (6): 13. (PMID: 18713594)

▪ Zenggang Pan, Bo Wang. Anaplastic Carcinoma of the Pancreas Associated with a Mucinous Cystic Adenocarcinoma: A Case Report and Review of the Literature. Journal of the Pancreas. 2007; 8(6) (PMID: 17993730)

▪ Shuping Shi, Zifen Gao, Zenggang Pan. Multifocal Cutaneous Angiocentric Lymphoma. Chinese Journal of Pathology. 1997 March; 26(3); 164.

  ONLINE CASE STUDIES

▪ Zenggang Pan, Jeff Wang, Nhi Huynh, Susan Repertinger and Deba P Sarma. Vascular Spiradenoma. The Internet Journal of Dermatology. 2009, 7 (1).

▪ Zenggang Pan, Susan Repertinger. An Adrenal Myelolipoma with Infiltration of Chronic Lymphocytic Leukemia. The Internet Journal of Pathology. 2008, 7 (1).

▪ Zenggang Pan, Nhi Huynh and Deba P Sarma. Fibroepithelioma of Pinkus in a 9-Year-Old Boy: a Case Report. Cases Journal. 2008, 1:21.

▪ Zenggang Pan, Deng Caishu, Edward D. Adickes. An Oncocytoma Associated With Acquired Cystic Disease of Kidney: A Case Report And Review Of The Literature. The Internet Journal of Nephrology. 2008, 4 (2).

▪ Zenggang Pan, William J. Hunter: Hydatid Cyst Of The Liver: A Case Report And Review Of The Literature. The Internet Journal of Parasitic Diseases. 2007, 2 (1).

▪ Zenggang Pan, Deba P. Sarma. Solitary Nasal Fibrofolliculoma. The Internet Journal of Dermatology. 2007, 5 (2).

▪ Zenggang Pan, Deba P. Sarma. Dedifferentiated Chondrosarcoma: A Case Report And Review Of The Literature. The Internet Journal of Orthopedic Surgery. 2007, 5 (1).

▪ Zenggang Pan, Deba P. Sarma. Pigmented Neurofibroma of the Skin: a Case Report and Review of the Literature. The Internet Journal Dermatology. 2007, 5(1).

  CONFERENCES AND ABSTRACTS

▪ Zenggang Pan, Zhengbin Lu, Lanting Liu, David Wilson, Vishnu Reddy, Huanyou Wang, Yongsheng Ren. Extracavitary KSHV+ Large B-Cell Lymphoma: Time to Have a New Name? The United States and Canadian Academy of Pathology's 100th Annual Meeting, Feburary 26 - March 4, 2011, San Antonio, TX (Poster)

▪ Zenggang Pan, William Grizzle, and Omar Hameed. Immunohistochemical Expression of Renal Markers in Matched Primary and Metastatic Renal Cell Carcinomas. The United States and Canadian Academy of Pathology's 100th Annual Meeting, Feburary 26 - March 4, 2011, San Antonio, TX (Poster)

▪ Zenggang Pan, Min Li, Omar Hameed, Wing C. Chan, and Zifen Gao.Classification of Diffuse Large B-Cell Lymphoma with a New Algorithm and Evaluation of GCET2 in the Classification System. The United States and Canadian Academy of Pathology's 100th Annual Meeting, Feburary 26 - March 4, 2011, San Antonio, TX (Poster)

▪ Zenggang Pan, William J. Hunter, Caishu Deng. Postmortem Diagnosis of Hodgkin Lymphoma: an Issue Regarding to Needle Core Biopsy. The United States and Canadian Academy of Pathology's 99th Annual Meeting, March 20-26, 2010, Washington, DC (Poster)

▪ Zanggang Pan, Poonam Sharma, Brian Loggie and Zoran Gatalica. Thymidylate Synthase Expression in Pseudomyxoma Peritonei Correlates with the Grade of Malignancy (abstract submission #2003). The United States and Canadian Academy of Pathology's 97th Annual Meeting, March 1-7, 2008, Denver, CO. (Poster)

▪ Zenggang Pan, Yulei Shen, Baosheng Ge, Cheng Du, Timothy McKeithan, Wing C Chan. Study of GCET2 Indicates its Role as an Adaptor Protein in B Cell Signaling. The American Society of Hematology 47th Annual Meeting and Exposition. December 3-6, 2005. Atlanta, Georgia. (Poster)

▪ Zenggang Pan, Yulei Shen, Baosheng Ge, Cheng Du, Timothy McKeithan, Wing C Chan. GCET2, a New Adaptor Protein in B-Cell Signaling. 37th Annual Midwest student biomedical research forum, Omaha, NE. 2006 (Poster)

▪ Zenggang Pan, Yulei Shen, Cheng Du, Guimei Zhou, Andreas Rosenwald, Louis M. Staudt, Timothy C. Greiner, Timothy W. McKeithan and Wing C. Chan.. Two Newly Characterized Germinal Center B-Cell Associated Genes, GCET1 and GCET2, with Differential Expressions in Normal Germinal Center B-Cells and Associated Lymphomas. 34th Annual Midwest student biomedical research forum, Omaha, NE. 2003 (Poster)

▪ Pan Zenggang, Gao Zifen, Wang Honghai, Faith Ho. Comparative Studies of Nasopharyngeal B-Cell Lymphomas in Hong Kong and Beijing. Tai Yuan, Shan Xi, China. June, 1998. (Oral presentation)

▪ 2001 Beijing International Lymphoma Symposium (Committee member of the meeting). Key speakers: Dr. Dennis D. Weisenburger, Dr. Wing C. Chan, and Dr. Bharat N. Nathwani. Beijing, China. August, 2001.

▪ 1999 Beijing International Lymphoma Symposium (Committee member of the meeting). Key speakers: Dr. H. Konrad Müller-Hermelink and Dr. Alfred C. Feller. Beijing, China. June 1999.

  CERTIFICATION AND LICENSURE

▪ American Board of Pathology, Certified, Anatomic and Clinical Pathology, 08/2010

▪  USMLE Step I, 01/27/05

▪  USMLE Step II, CK 10/18/05

▪  USMLE Step II, CS 11/17/05

▪  ECFMG #0-662-051-2. Certified, 01/12/2006

▪  USMLE Step III, 03/15/2007

▪  Temporary Education Permit (TEP) #5402

▪  BCLS and ACLS

▪  Chinese Medical Board Certificate, 11/1999

  MEMBERSHIPS

▪  American Medical Association (AMA), #24347970031

▪  American Society for Clinical Pathology (ASCP), #4183730

▪  College of American Pathologists (CAP), #1134205

▪  United States and Canadian Academy of Pathology (USCAP), #21535

▪  American Society of Hematology (ASH), # 100728

▪  Nebraska Association of Pathologists (NAP), #901703

▪  Nebraska Medical Association (NMA)

▪  Metropolitan Omaha Medical Society (MOMS)

  HONORS AND AWARDS

▪  2009 Resident Research Grant Award from CAP Foundation

▪  34th Annual Midwest Student Biomedical Research Forum, Omaha, NE, 2003

·  Second-Place Award in Poster Presentation (Basic science category)

·  Third-Place Award in Poster Presentation (Graduate student/Resident category)

▪  Distinguished Pathology Teacher, Beijing Medical University, 1999

▪  Distinguished Pathology Teacher, Beijing Medical University, 1998

  TEACHING EXPERIENCE

    ▪  Medical School Teaching (2006-2009, Creighton University Medical Center)

     · Anatomy graduate students (39 students total). Introduction of grossing procedures and techniques. January - May.

     · Fourth year medical students (36 students total).  Daily guidance into a broad introduction in the practice of pathology in the art of

       gross description, microscopic evaluation and diagnosis.

    ▪  Medical School Teaching (1997-2000, Peking University Health Science Center)

    · Medical student pathology lectures (350 students annually). Inflammation, pulmonary system, kidney, and cardiovascular system.

    · Medical student pathology small group (50 students annually). Basic pathology, gross and microscopic description and diagnosis.

    ▪  Interdisciplinary Teaching

    · Tumor Board Interdisciplinary Patient Care Conference (weekly conference involving Surgery, Pathology, and Radiology).

      Conduction and Presentation of Pathology Component.

    · Hospital Grand Rounds Presentations

· GCET2, a new adaptor protein in germinal center B-cell signaling. January 2, 2007.

· Thymidylate synthase expression in pseudomyxoma peritonei. April 22, 2008.

· GCET1 and GCET2 in classification of lymphomas. April 28. 2009.

  OTHER ACTIVITIES

▪ Chairperson (2002-2005). The Chinese Student and Scholar Association, University of Nebraska Medical Center, Omaha, Nebraska.

▪  Member of the IT group (Current), Chinese American Pathologists Association (CAPA).

▪  CAP Inspections

o  Clinical pathology, Converge Diagnostic Services, Peabody, Massachusetts. February 15, 2008.

o  Anatomic pathology, Department of Pathology, Creighton University Medical Center. June 8, 2008.