ANCA

Microscopic Polyangiitis

Wegener's Granulomatosis

Churg-Strauss Syndrome

PR3-ANCA

40%

75%

10%

MPO-ANCA

50%

20%

60%

Negative

10%

5%

30%

Immunofluorescence Pattern

Antigen

Associated Disease

C-ANCA

Coarsely granular cytoplasmic pattern with central and interlobular accentuation

PR3

Wegener's granulomatosis
Microscopic polyarteritis
Churg-Strauss syndrome

P-ANCA

Perinuclear cytoplasmic with nuclear extension

Caused by artifactual redistribution of the MPO antigen to the nucleus during substrate preparation

MPO

Microscopic polyarteritis
Necrotizing and crescentic glomerulonephritis
Churg-Strauss syndrome
Classic polyarteritis nodosa
Wegener's granulomatosis
SLE
Rheumatoid arthritis
Chronic IBD