Differences Between Reactive Mesothelial Cells and Mesothelioma

 

 

Uploaded: 2007-08-18,  Updated: 2007-08-18

 

Reactive Mesothelial Cells

Mesothelioma
Fewer cells High cellularity
Smaller, less complex groups Larger, more complex groups
Flat sheets, knobby, flower-like aggregates Irregular, 3-dimensional, papillary aggregates, many cell-in-cell
Cells enlarged with reactive changes Larger and more pleomorphic, common multinucleated giant cells
Reactive nuclear changes, monomorphic nuclei Malignant nuclear changes, pleomorphic nuclei
Prominent nucleoli Prominent nucleoli, macro-nucleoli and multiple

 

Reference
 

  • The art and science of cytopathology. Richard M Demay, MD. 1996
  Summarized by Zenggang Pan, MD, PhD