Case 38  - Discussion


   

HMB45, 4

HMB45, 10
MART1, 4 MART1, 10
MITF, 4 MITF, 10
S100, 4 S100, 10
   
   
 

Malignant melanoma, Clark's Level IV.

 
  Malignant Melanoma Parameters:
  • Clinical: Tumor Location: Left thigh
  • Sex, age: Female, 80 years old
  • Macroscopic: Biopsy
  • Tumor size: Greatest dimension: 8 mm
  • Microscopic:
  • Histologic subtype: Melanoma in pre-existing nevus.
  • Tumor thickness: 0.9 mm
  • Clark's Level: IV (in reticular dermis)
  • Ulceration: Absent
  • Mitotic rate: >6 per mm^2 (high)
  • Angiolymphatic invasion: Absent
  • Host inflammation: Absent
  • Regression: Absent
  • Microscopic satellites: Absent
  • Margin status: Positive
  • Pathologic Stage (pTNM) (Micro staging): pT1, pNX, pMX.