Case 1 - Discussion



lupus Erythematosus Cell (LE Cell)


LE Cell ( or hemotoxylin body): 

  • Mature neutrophils or monocytes with an inclusion of homogeneous staining degenerated nucleoprotein and antibody to nucleoprotein. They suggest SLE but are found in many diseases.

  • Certain antinuclear antibodies can enter into viable cells, which results in protracted active cell death.

  • The material engulfed by LE cells are apoptotic blebs as residuals of cells dying after penetration of anti-DNA antibodies.

  • LE cells are not usually found in peripheral blood, but in synovial fluid, cerebrospinal fluid and pericardial, pleural effusions and bone marrow from patients with SLE.

Tart Cell: a macrophage or monocytoid reticuloendothelial cell that contains a phagocytized nucleus with well-preserved nuclear structure; the phagocytized nucleus, as distinguished from an LE cell inclusion, shows an intact chromatin pattern and chromatin that is more dense and tends to become vacuolated, and is frequently smaller than that in a true LE cell.

  Rheumatology 2001; 40: 826-827
  Blood, 1955, Vol. 10, No. 7, pp. 718-729.